Analysis of the sheep trichohyalin gene: potential structural and calcium-binding roles of trichohyalin in the hair follicle.
May 1993
in “
The Journal of Cell Biology
”
Research cited in this study
12 / 12 resultsresearch Trichohyalin: Purification from Porcine Tongue Epithelium and Characterization of the Native Protein
research Trichohyalin: Presence in the Granular Layer and Stratum Corneum of Normal Human Epidermis
Trichohyalin is also found in the outer layers of normal human skin.
research Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle.
Keratins K1 and K10 are found in the inner root sheath and cuticle of human hair follicles.
research Cyclic hair-loss and regrowth in transgenic mice overexpressing an intermediate filament gene.
research The cDNA-Deduced Amino Acid Sequence for Trichohyalin, a Differentiation Marker in the Hair Follicle, Contains a 23 Amino Acid Repeat
Trichohyalin, a hair follicle protein, has a part with repeating patterns of 23 amino acids.
research Expression of hair-related keratins in a soft epithelium: Subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation
research Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles
research Cell Differentiation in Human Anagen Hair and Hair Follicles Studied with Anti-Hair Keratin Monoclonal Antibodies
research Trichohyalin, an Intermediate Filament-Associated Protein of the Hair Follicle
Trichohyalin is a protein in hair follicles that helps form hair filaments.
research Immunological characteristics and histological distribution of human hair fibrous proteins studied with anti-hair keratin monoclonal antibodies HKN-2, HKN-4, and HKN-6.
The study used monoclonal antibodies HKN-2, HKN-4, and HKN-6 to investigate the immunological characteristics of human hair fibrous proteins. HKN-2 and HKN-4 marked both hair and epidermal fibrous proteins, while HKN-6 was specific to hair fibrous proteins. Immunohistochemical analysis showed that all three antibodies stained the keratogenous zone of anagen hairs, with HKN-6 being specific to hair and not reacting with other skin components or tissues. HKN-2 reacted with skin epithelial tissues but was limited to the skin, whereas HKN-4 showed broad crossreactivity with various epithelial cells. The findings suggested that some hair fibrous proteins were specific to hair cells, while others crossreacted with proteins in other epithelial cells, indicating the potential of these antibodies in studying epithelial cell differentiation.
research The Origin of Citrulline-Containing Proteins in the Hair Follicle and the Chemical Nature of Trichohyalin, an Intracellular Precursor
research Formation of the Iε-(γ-Glutamyl)Lysine Crosslink in Hair Proteins: Investigation of Transamidases in Hair Follicles
Transamidases help form strong crosslinks in hair proteins, crucial for hair strength.
Related Research
6 / 6 resultsresearch TRPV3 Gain-of-Function Mutation Impairs Differentiation of Hair Follicle Inner Root Sheath
A specific mutation in the TRPV3 gene causes hair follicle cells to develop improperly, leading to hair loss.
research Functional analysis of keratin components in the mouse hair follicle inner root sheath
Keratin in mouse hair follicles is complex and plays specific roles.
research Expression of E6 and E7 papillomavirus oncogenes in the outer root sheath of hair follicles extends the growth phase and bypasses resting at telogen.
research Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles
EGF makes hair follicles grow longer but stops hair production.
research Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro
research Outer root sheath keratinization in anagen and catagen of the mammalian hair follicle. A seventh distinct type of keratinization in the hair follicle: trichilemmal keratinization.
The study described trichilemmal keratinization as a distinct type of keratinization in the hair follicle, characterized by the conversion of the outer root sheath's stratified epithelium into anuclear keratin without a keratohyalin layer. This process was observed in the anagen phase below the sebaceous duct opening and in the catagen phase within the trichilemmal sac. The research, using electron microscopy on dog hairs, revealed complex infoldings of cells and unique ladder-like membrane coating granules in anagen, which were acid phosphatase-positive and potentially involved in the disintegration of the inner root sheath.