An In Vitro Model for the Morphogenesis of Hair Follicle Dermal Papillae
August 2013
in “Journal of Investigative Dermatology”
TLDR Scientists created a model using sheep cells to study hair root formation, which can test how different substances affect hair growth.
The document from 2013 details the creation of an in vitro model using sheep dermal papilla cells (DPCs) to study hair follicle dermal papillae morphogenesis. The study demonstrated that these cells can form stable aggregates, mimicking natural dermal papillae behavior, and can be used to measure the effects of compounds on these structures. The researchers found that the cells formed spheroids expressing markers of dermal papillae and established a quantitative assay for aggregate size. They also discovered that lithium chloride reduced aggregate size, while minoxidil counteracted this effect. The model, which remained consistent over multiple cell passages, provides a valuable tool for exploring the regulation of dermal papillae size.
View this study on jidonline.org →
Cited in this study
research De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle
New cells are added to the hair's dermal papilla during the active growth phase.
research Biology of the wool follicle: an excursion into a unique tissue interaction system waiting to be re‐discovered
The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.
research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle
Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
Related
research Dermal papilla regulation of hair growth and pigmentation
Dermal papilla cells are key for hair growth and color, influencing hair type and size, and their interaction with stem cells could help treat hair loss and color disorders.
research An In Vitro Model for the Morphogenesis of Hair Follicle Dermal Papillae
Scientists created a model using sheep cells to study hair root formation, which can test how different substances affect hair growth.
research β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
β-catenin in the dermal papilla is crucial for normal hair growth and repair.
research Dermal papilla cells induce keratinocyte tubulogenesis in culture
Skin cells can help create early hair-like structures in lab cultures.
research Trans‐species hair growth induction by human hair follicle dermal papillae
Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
research Dermal-epidermal interactions
The dermal papilla interacts with the epidermis to control hair growth and development.