TLDR A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.
In 2014, researchers developed a new synthesis method for the anti-baldness compound RU58841, which was more efficient and less toxic than the previous method. The old method used phosgene, a toxic gas, and required multiple steps under an inert atmosphere and flash chromatography. The new method did not use phosgene, required only one inert atmosphere step, and did not require flash chromatography. The overall yield of the new synthesis was 33%. The researchers also found that bromine-nitro substitutions can occur on tertiary carbons with a neighboring carbonyl, and that 2-nitropropane can be an effective leaving group, enabling the formation of a hydantoin ring by cyclization.View this study on pubs.rsc.org →
RU58841 significantly increases hair growth rate and initiates more hair cycles, but doesn't affect hair thickness, suggesting it could be a new treatment for baldness.
Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.
RU 58841 may treat acne, hair loss, and excessive hair growth.