Alterations in neonatal neurosteroids affect exploration during adolescence and prepulse inhibition in adulthood

September 2009 in “ Psychoneuroendocrinology ”

Sònia Darbra, Marc Pallarés

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research Neonatal Finasteride Induces Anxiogenic-Like Profile and Deteriorates Passive Avoidance in Adulthood After Intrahippocampal Neurosteroid Administration

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Finasteride given to baby rats causes anxiety-like behavior and worsens learning from punishment in adult rats.

research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

61 citations , January 2008 in “Biological & Pharmaceutical Bulletin”

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

research The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches

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research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

98 citations , April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively blocks rat enzymes, but with varying methods and strength.