Alopecia Associated with Sulfasalazine

    February 1994 in “ Drug Investigation ”
    Peter I. Pillans, David Woods
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    TLDR Sulfasalazine might cause hair loss, especially in women, and stopping it can reverse the hair loss.
    The document described a potential link between sulfasalazine use and alopecia, based on 24 cases from a database of 24,784 adverse reaction reports. Of these cases, 4 were classified as having a probable causal association and 20 as possible. The affected patients were between 8 and 74 years old, with an average age of 36.8 years, and the majority (18 out of 24) were female. Hair loss typically occurred after 2 to 6 months of sulfasalazine therapy. In 5 cases, hair growth resumed after the drug was discontinued. The findings suggest that there may be a causal relationship between sulfasalazine and hair loss, especially considering the gender distribution, timing of hair loss onset, and the reversal of alopecia after stopping the medication.
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