Alopecia Associated with Sulfasalazine

The document described a potential link between sulfasalazine use and alopecia, based on 24 cases from a database of 24,784 adverse reaction reports. Of these cases, 4 were classified as having a probable causal association and 20 as possible. The affected patients were between 8 and 74 years old, with an average age of 36.8 years, and the majority (18 out of 24) were female. Hair loss typically occurred after 2 to 6 months of sulfasalazine therapy. In 5 cases, hair growth resumed after the drug was discontinued. The findings suggest that there may be a causal relationship between sulfasalazine and hair loss, especially considering the gender distribution, timing of hair loss onset, and the reversal of alopecia after stopping the medication.