Alopecia Areata After Hepatitis C Virus Infection Treatment: A Case Report

April 2021 in “ Anatolian current medical journal : ”

Esma Eroğlu

alopecia areata interferon-free direct-acting antiviral therapy sofosbuvir ribavirin chronic hepatitis C virus infection DAA therapy SOF/RBV HCV

Studysummary This case report highlights that a patient developed alopecia areata following treatment with sofosbuvir and ribavirin for chronic hepatitis C.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

A case report from April 2021 described a rare instance of alopecia areata developing in a patient following treatment with the interferon-free direct-acting antiviral (DAA) therapy combination of sofosbuvir and ribavirin (SOF/RBV) for chronic hepatitis C virus (HCV) infection. Despite the generally low side effects associated with DAA therapies, this case highlighted alopecia areata as a potential, though uncommon, complication.

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Research cited in this study

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Lichen Planus and Other Cutaneous Manifestations in Chronic Hepatitis C: Pre- and Post-Interferon-Based Treatment Prevalence in a Cohort from a Low Hepatitis C Virus Endemic Area

research Lichen Planus and Other Cutaneous Manifestations in Chronic Hepatitis C: Pre- and Post-Interferon-Based Treatment Prevalence in a Cohort from a Low Hepatitis C Virus Endemic Area

34 citations , April 2008 in “Journal of the European Academy of Dermatology and Venereology”

This study reported that while lichen planus was not significantly linked to hepatitis C virus infection, pruritus, dry skin, and hair loss were more common in HCV patients post-interferon treatment.

Reversible Alopecia Universalis Secondary to PEG-Interferon Alpha-2b and Ribavirin Combination Therapy in a Patient with Chronic Hepatitis C Virus Infection

research Reversible Alopecia Universalis Secondary to PEG-Interferon Alpha-2b and Ribavirin Combination Therapy in a Patient with Chronic Hepatitis C Virus Infection

41 citations , August 2007 in “European Journal of Gastroenterology & Hepatology”

This case report documents a reversible instance of complete body hair loss (alopecia universalis) in a patient undergoing chronic hepatitis C treatment with pegylated interferon alpha-2b and ribavirin, with hair regrowth observed within three months after therapy completion.

research Reversible Alopecia Universalis During Treatment with PEG-Interferon and Ribavirin for Chronic Hepatitis C

27 citations , April 2005 in “Journal of Chemotherapy”

This study reported two cases of alopecia universalis triggered by PEG-interferon and ribavirin therapy for chronic hepatitis C, with hair regrowth observed after therapy completion or withdrawal.