Alopecia in Association with Lamotrigine Use

    July 2010 in “ Drug safety ”
    Maria Tengstrand, Kristina Star, Eugène van Puijenbroek, Richard L. Hill
    TLDR Lamotrigine may cause hair loss, affecting treatment compliance and health.
    The study analyzed 337 reports from 19 countries in the WHO global ICSR database, VigiBase, where lamotrigine was suspected of causing alopecia. The patients ranged from 5 months to 84 years old, with a mean age of 36 years, and 58% were under 40 years old. The majority (272) were female. In 291 cases, lamotrigine was the only drug suspected, and in 112 cases, it was the sole reported drug. Alopecia was the single event in 217 reports. In 11 cases, alopecia resolved after stopping lamotrigine, and one patient experienced a recurrence upon re-administration. The study concluded that while alopecia is not considered serious from a regulatory perspective, it could impact treatment compliance and patient health outcomes.
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