Allergic and irritant contact dermatitis compared in the treatment of alopecia totalis and universalis. A comparison of the value of topical diphencyprone and tretinoin gel

The study compared the effectiveness of topical diphencyprone (DPCP) and tretinoin gel in treating alopecia totalis and universalis, focusing on allergic and irritant contact dermatitis. The research concluded that DPCP was more effective in inducing hair regrowth compared to tretinoin gel. The study highlighted the importance of allergic contact dermatitis in the therapeutic mechanism of DPCP, whereas tretinoin gel, which primarily caused irritant contact dermatitis, was less effective. The findings suggested that DPCP could be a more valuable treatment option for patients with severe forms of alopecia.