Fructose-1,6-Bisphosphate Aldolase A Levels Decrease in Hair Keratinocytes During Androgenetic Alopecia

November 2013 in “ International Journal of Dermatology ”

Takumi Tochio, Hiroshi Tanaka, Satoru Nakata, Hiroshi Hosoya

fructose-1,6-bisphosphate aldolase A ALDOA hair keratinocytes androgenetic alopecia AGA vellus hairs hair shaft elongation

TLDR ALDOA levels drop in hair cells during hair loss.

Levels of fructose-1,6-bisphosphate aldolase A (ALDOA) decrease in hair keratinocytes during androgenetic alopecia (AGA). ALDOA is involved in the morphological alteration of hair keratinocytes during elongation of hair shafts, and a decrease in ALDOA in vellus hairs might be involved in reduced hair shaft elongation. However, the mechanism behind the association of ALDOA with the progression of AGA remains to be fully clarified. Further studies are needed to elucidate the involvement of ALDOA in AGA.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

19 citations, January 1997 in “Endocrinology”

Testosterone can slow hair growth in adult monkeys, but a blocker called RU 58841 can counteract this and potentially help hair regrow.

Related Community Posts Join

5 / 5 results

community this community is so funny bro

in Satire 1761 upvotes 3 weeks ago

Hair loss treatments like finasteride, minoxidil, and dutasteride are discussed, with users sharing mixed experiences about effectiveness and side effects. Some users report positive results, while others express concerns about side effects, highlighting the importance of personal choice.

community A New Therapeutic Channel to Come Soon: Hair Follicle Sugar Metabolism and Aldose Reductase

in Research/Science 131 upvotes 3 years ago

Hair loss therapies focusing on hair follicle sugar metabolism and aldose reductase. Potential treatments include magnesium supplements, avoiding high glycemic index foods, and antioxidants.

community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

in Female 42 upvotes 3 years ago

User "missbloombastic" has been experiencing hair loss since 2016 and tried min, fin, multivitamins, and spiro with mixed results. Another user shares their struggle with hair loss and its impact on self-esteem, while a third user suggests checking blood tests and confirming the cause of hair loss.

community Is 2-deoxy-D-ribose (2dDR) good for human hair?

in Research/Science 9 upvotes 2 months ago

Topical 2-deoxy-D-ribose (2dDR) regrows hair in mice almost as well as 2% Minoxidil. However, 2dDR may contribute to oxidative stress and hair loss due to the formation of advanced glycation end products (AGEs).

community Red Ginseng Extract Promotes the Hair Growth in Cultured Human Hair Follicles

17 upvotes 6 years ago

The conversation is about hair loss treatments, specifically discussing the effectiveness of Red Ginseng Extract in promoting hair growth. Other treatments mentioned include Minoxidil, finasteride, and RU58841.

Related Research

1 / 1 results

research Fructose-1,6-Bisphosphate Aldolase A Levels Decrease in Hair Keratinocytes During Androgenetic Alopecia

2 citations, November 2013 in “International Journal of Dermatology”

ALDOA levels drop in hair cells during hair loss.