Acute Generalized Exanthematous Pustulosis Induced by Plaquenil

This case study examines a 67-year-old Greek female with rheumatoid arthritis who developed acute generalized exanthematous pustulosis (AGEP) after starting Plaquenil therapy. Within 10 days, she experienced a spreading rash, initially misdiagnosed as a viral infection and Hand, Foot, and Mouth Disease, delaying proper treatment. Elevated white blood cell count and punch biopsies confirmed AGEP. Discontinuation of Plaquenil and treatment with corticosteroids and topical cream led to significant improvement. The study highlights the challenges of diagnosing AGEP early and stresses the importance of accurate and timely diagnosis to prevent complications.