Adverse Effects of Medications on Male Fertility: Study in the Vigibase Database

The study conducted by Alix Hocede in 2017 analyzed the adverse effects of medications on male fertility using data from the global Vigibase database. It was a descriptive and retrospective study that identified 1923 cases reported between 1981 and November 25, 2016. The number of reports increased over time, especially since 2008, with most patients being between 18 and 44 years old. The main classes of medications implicated included those for the genitourinary system and sex hormones, nervous system, dermatology, cardiovascular system, antineoplastics and immunomodulators, and digestive and metabolic systems. Notable medications associated with male infertility were finasteride, testosterone, valproic acid, acetylsalicylic acid, and dutasteride. The study highlighted both well-known and unexpected drugs contributing to male infertility.