Adverse Drug Reactions Reported in 1978

    January 1978 in “ Clin-Alert ”
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    TLDR A document listed serious side effects from various drugs, including deaths and diseases, emphasizing the importance of being aware of drug side effects.
    In 1978, a document reported various adverse drug reactions, including a 43-year-old man who died from sclerosing peritonitis after taking propranolol, a 28-year-old woman developing myasthenia gravis from penicillamine, a 72-year-old woman experiencing hemarthrosis from warfarin and heparin, and a 15-year-old boy with a hypersensitivity reaction to hydroxyzine. Additionally, bile duct carcinoma was linked to isoniazid, Raynaud's phenomenon to bleomycin and vinblastine, renal failure and death to co-trimoxazole, telogen effluvium to a liquid protein diet, psychotic symptoms to dipipanone, and agranulocytosis and death to fenoprofen. The FDA was removing pediatric tetracycline due to dental issues, and a dangerous blood pressure drop was associated with phenytoin and dopamine. A 38-year-old woman developed Stevens-Johnson syndrome after taking cimetidine, highlighting the need for awareness of drug side effects.
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