Phenyl Propanoid 1'S-1'-Acetoxychavicol Acetate Protects Against Testosterone-Induced Alopecia by Inhibiting NADPH Oxidase

April 2025

Kkotnara Park, Isoo Youn, Jung Min Suh, Min Hye Choi, Da-Woon Bae, Soo-Bong Park, Mi Hee Kwack, Mi Hee Kwack, Young Kwan Sung, Dae Sik Jang, Yun Soo Bae, Eun Kyoung Seo

1'S-1'-acetoxychavicol acetate testosterone-induced alopecia NADPH oxidase keratinocyte apoptosis reactive oxygen species hydrogen peroxide androgenetic alopecia Alpinia galanga ACA testosterone ROS hair follicle hair loss androgenic alopecia

TLDR ACA from Alpinia galanga may prevent testosterone-related hair loss.

The study explores the effects of 1'S-1'-acetoxychavicol acetate (ACA) on testosterone-induced alopecia, highlighting its potential as a therapeutic agent for androgenetic alopecia (AGA). ACA was found to inhibit NADPH oxidase (Nox), reducing reactive oxygen species (ROS) production and keratinocyte apoptosis, which are linked to hair loss. In human hair follicle cultures and a mouse model, ACA improved hair growth suppressed by testosterone, indicating its promise as a treatment for male hair loss with potentially fewer side effects compared to conventional therapies.

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Phenyl Propanoid 1'S-1'-Acetoxychavicol Acetate Protects Against Testosterone-Induced Alopecia by Inhibiting NADPH Oxidase

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