Role of Testosterone in SARS-CoV-2 Infection: A Key Pathogenic Factor and a Biomarker for Severe Pneumonia

May 2021 in “ International Journal of Infectious Diseases ”

Marta Camici, Paolo Zuppi, Patrizia Lorenzini, L. Scarnecchia, Carmela Pinnetti, Stefania Cicalini, Emanuele Nicastri, Nicola Petrosillo, Fabrizio Palmieri, Gianpiero D’Offizi, Luisa Marchioni, Roberta Gagliardini, Roberto Baldelli, Vincenzo Schininà, Elisa Pianura, Federica Di Stefano, Stefano Curcio, Lucia Ciavarella, Giuseppe Ippolito, Enrico Girardi, Francesco Vaia, Andrea Antinori

testosterone androgenetic alopecia TMPRSS2 receptor

Studysummary This study found that lower testosterone levels in male COVID-19 patients were associated with greater disease severity and longer hospital stays.

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Proxalutamide Significantly Accelerates Viral Clearance and Reduces Time to Clinical Remission in Patients with Mild to Moderate COVID-19: Results from a Randomized, Double-Blinded, Placebo-Controlled Trial

research Proxalutamide Significantly Accelerates Viral Clearance and Reduces Time to Clinical Remission in Patients with Mild to Moderate COVID-19: Results from a Randomized, Double-Blinded, Placebo-Controlled Trial

41 citations , February 2021 in “Cureus”

In this study, Proxalutamide significantly increased the rate of viral clearance and reduced clinical remission time in patients with mild to moderate COVID-19 compared to placebo.

research Androgenetic Alopecia Present in the Majority of Patients Hospitalized with COVID-19: The 'Gabrin Sign'

119 citations , May 2020 in “Journal of The American Academy of Dermatology”

This study observed a high prevalence of androgenetic alopecia in patients hospitalized with severe COVID-19, with 79% of men and 42% of women affected, suggesting a potential link between androgen sensitivity and COVID-19 severity.