Alkaline Phosphatase in Alopecia Areata

    September 1957 in “ Archives of Dermatology ”
    Alfred W. Kopf
    From the encyclopedia
    Alopecia Areata →

    autoimmune disorder causing patchy hair loss

    Hydrocortisone →

    a synthetic cortisol used for anti-inflammatory effects

    Studysummary This study investigated alkaline phosphatase activity in scalp biopsies from patients with alopecia areata and totalis, but provides no new conclusive clinical results.
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    The study investigates the role of alkaline phosphatase (A.P.) in alopecia areata and alopecia totalis by analyzing 10 scalp biopsies from patients at different stages of hair loss and regrowth. Previous reports indicated a decrease in A.P. activity in hair papillae during early alopecia areata. This research aims to further understand A.P. activity in these conditions, including areas treated with hydrocortisone injections. The precise role of A.P. in cutaneous metabolic processes remains unclear, but its activity is linked to various biochemical processes and may influence hair loss and regrowth.
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