March 2025 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft” In this case report, the authors found that pigmented demodicosis, caused by Demodex mites, led to facial hyperpigmentation in a 16-year-old male and showed significant improvement with oral isotretinoin and topical ivermectin treatment.
February 2022 in “Cleveland Clinic Journal of Medicine” This case report observed hypertrichosis on the left forearm of an 80-year-old woman, possibly linked to her previous use of the topical steroid betamethasone butyrate propionate for dermatitis.
June 2026 in “Dermatology and Therapy” This review provides an analysis of topical treatments with clinically proven efficacy for managing hyperpigmentation and concludes that the most effective approach is using combined therapies that target multiple aspects of skin pigmentation physiology.
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September 2012 in “Pediatric Dermatology” This case report describes a 5-year-old boy with extensive epidermal nevus who experienced marked improvement using a topical calcipotriol/betamethasone dipropionate combination ointment.
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December 2024 in “Case Reports in Dermatology” In this case study, the researchers reported a rare incidence of bilateral hyperpigmented macules on a patient's lower legs, possibly due to cyclophosphamide, suggesting that this chemotherapy drug may directly stimulate hair follicles to cause skin discoloration.