In Vivo Silica Nanoparticle Translocation Across Human Stratum Corneum: The Effect of Surface Hydrophobization in Relation to Hair Follicle Density
January 2013
in “
IRIS UNIMORE (University of Modena and Reggio Emilia)
”
Studysummary This study found that silica nanoparticles penetrate the outer stratum corneum of human skin, with surface hydrophobization potentially enhancing this penetration.
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The study investigated the in vivo translocation of silica nanoparticles across the human stratum corneum (SC) and the effect of surface hydrophobization in relation to hair follicle density. Using tape stripping and EDX analysis on volunteers' forearms, it was found that silica nanoparticles could penetrate the outer SC, accumulating in the corneum disjunctum, with a significant decrease in deeper layers. The study revealed that hydrophobized silica (H-silica) enhanced penetration, suggesting that surface hydrophobization plays a role in facilitating nanoparticle movement across the SC. Hair follicle density did not significantly affect silica accumulation.
