August 2025 in “Pharmaceutics” This study evaluated methods to administer betulin in in vivo experiments and found that olive oil, food-grade lard, and other carriers increase betulin absorption in Wistar rats, while monitoring blood levels may aid future clinical research.
March 2024 in “International journal of pharmaceutical chemistry and analysis (Print)” In this study, albino wistar rats with testosterone-induced alopecia showed improved hair growth when treated with betulin, evidenced by increased hair length and decreased cholesterol and testosterone levels.
January 2026 in “In Silico Research in Biomedicine” This study used computational methods to explore the potential of betulinic acid from Ziziphus spina-christi in treating alopecia, suggesting its possible protective effects on hair follicles by enhancing genomic stability and reducing oxidative damage, meriting further experimental validation.
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June 2024 in “Archives of Dermatological Research” In this pilot study, researchers found that betulin did not conclusively inhibit hair loss or promote regrowth in patients with hypothyroidism when compared to placebo.
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July 2024 in “Journal of Investigative Dermatology” VYN201 shows promise as a safe and effective treatment for non-segmental vitiligo.