Tumor Necrosis Factor-Alpha and Polycystic Ovarian Syndrome: A Clinical, Biochemical, and Molecular Genetic Study

August 2014 in “ Genetic Testing and Molecular Biomarkers ”

Sujatha Thathapudi, Vijayalakshmi Kodati, Jayashankar Erukkambattu, Anuradha Katragadda, Uma Addepally, Qurratulain Hasan

Tumor Necrosis Factor-alpha TNF-α insulin resistance obesity Polycystic Ovarian Syndrome PCOS hyperandrogenism C850T polymorphism homeostatic model assessment HOMA score TNF-alpha

Studysummary This study suggests that the TNF-α system may contribute to hyperandrogenism, obesity, and insulin resistance in polycystic ovarian syndrome, independent of the C850T polymorphism.

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research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

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Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

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This article reviews the updated ESHRE/ASRM criteria for diagnosing polycystic ovary syndrome, emphasizing the need for continued research and collaboration, but reports no new clinical results.

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In this study, polycystic ovary syndrome was the most prevalent cause of androgen excess, and suppressive hormonal therapy improved hirsutism, menstrual dysfunction, and acne in most patients, though side effects were common.