TLDR Finasteride's negative effects on brain tissue in male rats may be reversible after stopping the drug.
The study investigated the effects of finasteride, a 5-alpha reductase inhibitor, on brain tissue in male rats. Eight rats were divided into three groups: control, finasteride, and finasteride withdrawal. After 4 weeks of finasteride administration, dihydrotestosterone levels and the dihydrotestosterone to testosterone ratio significantly decreased, but these levels improved after discontinuation of the drug. Brain tissue analysis showed reduced c-Fos protein activation due to finasteride, but this effect diminished after a month of stopping the drug. The study suggests that the negative impact of finasteride on brain tissue may be reversible.
November 2020 in “Journal of The American Academy of Dermatology” Finasteride 1 mg every other month works as well as daily dose for hair loss maintenance.
June 2019 in “Journal of Drug Delivery and Therapeutics” Finasteride effectively treats hair loss and prostate issues with minimal side effects.
January 2013 in “China Medical Abstract of Dermatology” Finasteride effectively reduces acne with minimal side effects.
12 citations
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October 2004 in “PubMed” Finasteride, especially in a 1mg dose, effectively slows hair loss and improves hair growth in Japanese men with male pattern hair loss.
38 citations
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June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Finasteride effectively improves hair growth and slows hair loss in men with male pattern baldness.
10 citations
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June 2001 in “PubMed” Finasteride is effective in growing hair and stopping hair loss in men with mild to moderate alopecia.
3 citations
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October 1995 in “International Journal of Dermatology” Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.
