The Effect of Administration and Discontinuation of Finasteride in Male Rats

March 2024 in “ The journal of sexual medicine ”

Dong Hoon Lee, Youn Jin Choi

finasteride 5-alpha reductase inhibitor dihydrotestosterone testosterone c-Fos protein Propecia DHT

TLDR Finasteride's negative effects on brain tissue in male rats may be reversible after stopping the drug.

The study investigated the effects of finasteride, a 5-alpha reductase inhibitor, on brain tissue in male rats. Eight rats were divided into three groups: control, finasteride, and finasteride withdrawal. After 4 weeks of finasteride administration, dihydrotestosterone levels and the dihydrotestosterone to testosterone ratio significantly decreased, but these levels improved after discontinuation of the drug. Brain tissue analysis showed reduced c-Fos protein activation due to finasteride, but this effect diminished after a month of stopping the drug. The study suggests that the negative impact of finasteride on brain tissue may be reversible.

View this study on academic.oup.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community [study analysis] Microdose of topical Finasteride for all the benefits and none of the sides?

in Research/Science 104 upvotes 4 years ago

Topical finasteride as a potential alternative to oral finasteride for reducing DHT levels on the scalp with fewer side effects, and other hair loss treatments such as minoxidil.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community FINASTRIDE and switch to DUTASTRIDE, my experience

in Progress Pictures 138 upvotes 3 months ago

The user shared their experience with Finasteride and Dutasteride for hair loss. They initially had success with Finasteride but switched to Dutasteride after experiencing shedding, which continued, and are now considering a hair transplant.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 97 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

Related Research

6 / 6 results

Similar Efficacy of Maintenance Treatment of Finasteride 1 mg Every Other Month Compared with Finasteride 1 mg Daily in Korean Men with Androgenetic Alopecia After Taking Finasteride 1 mg Daily for 1 Year

research Similar Efficacy of Maintenance Treatment of Finasteride 1 mg Every Other Month Compared with Finasteride 1 mg Daily in Korean Men with Androgenetic Alopecia After Taking Finasteride 1 mg Daily for 1 Year

November 2020 in “Journal of The American Academy of Dermatology”

Finasteride 1 mg every other month works as well as daily dose for hair loss maintenance.

research Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases

3 citations, October 1995 in “International Journal of Dermatology”

Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.