Vitamin- d3
Research
20 / 1000+ results
research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
This research highlights that engineered mice lacking the vitamin D receptor show multiple health issues similar to human vitamin D deficiency, underscoring the widespread impacts of the vitamin D endocrine system.
research Vitamin D Receptor: New Assignments for an Already Busy Receptor
This minireview discusses a proposed model of the vitamin D receptor that explains how 1alpha,25(OH)2D3 can mediate both genomic and rapid responses through different ligand shapes and cellular locations, without presenting new research findings.
research Vitamin D: More Than a Bona Fide Hormone
This review explores the diverse physiological roles of the vitamin D endocrine system, discussing current research on receptor structure, transcription details, murine models, and alternative receptors, but reports no new findings.
research Vitamin D Receptor: Molecular Signaling and Actions of Nutritional Ligands in Disease Prevention
This study identified new dietary ligands for the human vitamin D receptor, including curcumin and gamma-tocotrienol, which may influence its biological functions.
research Vitamin D Metabolism and Function in the Skin
This review discusses the regulation and function of vitamin D and its receptor in skin cells, highlighting their roles in processes such as proliferation inhibition, differentiation, and innate immunity, but reports no new results.
research Vitamin D and the Skin: Physiology and Pathophysiology
This review examines the functions of vitamin D and its receptor in skin and explores how these are regulated, reporting no new clinical results.
research Genetic Disorders and Defects in Vitamin D Action
This article compares two rare genetic diseases, vitamin D-dependent rickets type 1 and type 2, focusing on their similar presentations of hypocalcemia and rickets in infancy, but reports no new clinical results.
research Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis
This study found that mice lacking the vitamin D receptor (VDR) developed skin tumors more rapidly than those with normal VDR activity, regardless of 1,25-dihydroxyvitamin D(3) presence.
research Vitamin D and the Skin: Focus on a Complex Relationship
This review explores the impact of vitamin D deficiency on the skin from a dermatological perspective, but reports no new clinical results.
research The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis
This study observed that the vitamin D receptor is crucial for hair follicle formation and altering tumor development in the Wnt signaling pathway, suggesting therapeutic potential for vitamin D analogues in related tumors.
research Extraskeletal Actions of Vitamin D
This review examines the impact of vitamin D signaling in extraskeletal tissues and notes that expected benefits from animal and cell studies have not been consistently replicated in human clinical trials.
research Mutations in the Vitamin D Receptor and Hereditary Vitamin D-Resistant Rickets
This abstract reviews hereditary vitamin D-resistant rickets, a rare genetic condition causing severe early childhood rickets, and reports no new results; effective treatment typically requires high doses of calcium to address hypocalcemia and secondary hyperparathyroidism.
research Overexpression of Hedgehog Signaling Is Associated With Epidermal Tumor Formation in Vitamin D Receptor-Null Mice
Lack of vitamin D receptor increases skin tumor risk by boosting hedgehog signaling.
research Does D Matter? The Role of Vitamin D in Hair Disorders and Hair Follicle Cycling
This article outlines the potential for upregulating the vitamin D receptor in treating hair disorders, emphasizing the need for further studies to evaluate vitamin D's role in the hair cycle.
research Vitamin D-Dependent Rickets Type II: Defective Induction of 25-Hydroxyvitamin D3-24-Hydroxylase by 1,25-Dihydroxyvitamin D3 in Cultured Skin Fibroblasts
This study found that measuring 24-OHase induction by 1,25(OH)2D3 in cultured skin fibroblasts is a sensitive test for detecting genetic defects in the 1,25(OH)2D effector pathway.
research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes
This study found that Hairless (Hr) acts as a corepressor of the vitamin D receptor (VDR) in human keratinocytes, blocking the action of vitamin D on keratinocyte differentiation.
research Vitamin D and the Skin
research Topographical and Developmental Studies on Target Sites of 1,25 (OH)₂ Vitamin D₃ in Skin
Vitamin D3 affects cell differentiation in specific skin areas.
research Quantification of the Vitamin D Receptor-Coregulator Interaction
This study found that both the natural ligand 1alpha,25(OH)(2)D(3) and the synthetic agonist LG190178 bind similarly to the vitamin D receptor's coregulator motifs, suggesting similar biological functions.
research Vitamin D and Androgen Receptor-Targeted Therapy for Triple-Negative Breast Cancer
This study found that AR/VDR-targeted agonist hormone therapy can inhibit cell viability in HR2-av triple-negative breast cancer cell lines through multiple mechanisms and may enhance the effects of chemotherapy.