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Efficient Genome Editing Using CRISPR/Cas9 Ribonucleoprotein Approach in iPS Cells for Recessive Dystrophic Epidermolysis Bullosa

research Efficient Genome Editing Using CRISPR/Cas9 Ribonucleoprotein Approach in iPS Cells for Recessive Dystrophic Epidermolysis Bullosa

April 2019 in “Journal of Investigative Dermatology”

Researchers fixed gene mutations causing a skin disease in stem cells, which then improved skin grafts in mice.

research CRISPR/Cas9-Based Targeted Genome Editing for Correction of Recessive Dystrophic Epidermolysis Bullosa Using iPS Cells

1 citations , September 2019 in “Journal of Investigative Dermatology”

The research showed that CRISPR/Cas9 can fix mutations causing a skin disease in stem cells, which then improved skin grafts in mice, but more work on safety and efficiency is needed.

research Advancing Skin Model Development: A Focus on a Self-Assembled, Induced Pluripotent Stem Cell-Derived, Xeno-Free Approach

January 2024 in “Journal of Tissue Engineering”

A new ethical skin model using stem cells offers a reliable alternative for dermatological research.

Keratinocytes and Adipose-Derived Mesenchymal Stem Cells: The Heir and the Spare to Regenerative Cellular Therapies for Difficult-to-Heal Skin Wounds

research Keratinocytes and Adipose-Derived Mesenchymal Stem Cells: The Heir and the Spare to Regenerative Cellular Therapies for Difficult-to-Heal Skin Wounds

November 2023 in “Linköping University medical dissertations”

Keratinocytes and adipose-derived stem cells can effectively heal difficult skin wounds.

research Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in In Vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures

10 citations , August 2021 in “Frontiers in cell and developmental biology”

Scientists made structures that look like human hair follicles using stem cells, which could help grow hair without using actual human tissue.

View more "xeno-free reprogramming" in research →

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community 2 months topical dutasteride plus minoxidil, very happy with the results!

in Finasteride/Dutasteride 339 upvotes 5 years ago

A user's success in treating their hair loss with 2x daily topical dutasteride and minoxidil, as well as the potential for using less frequent application of topical dutasteride due to its long half-life.

community In my opinion baldness is more prevalent now and it's being ignored..

in Chat 236 upvotes 2 years ago

The conversation is about the prevalence of baldness among young men and the potential factors contributing to it. Specific treatments mentioned include minoxidil and finasteride.