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Efficient Genome Editing Using CRISPR/Cas9 Ribonucleoprotein Approach in iPS Cells for Recessive Dystrophic Epidermolysis Bullosa

research Efficient Genome Editing Using CRISPR/Cas9 Ribonucleoprotein Approach in iPS Cells for Recessive Dystrophic Epidermolysis Bullosa

April 2019 in “Journal of Investigative Dermatology”

Researchers fixed gene mutations causing a skin disease in stem cells, which then improved skin grafts in mice.

research CRISPR/Cas9-Based Targeted Genome Editing for Correction of Recessive Dystrophic Epidermolysis Bullosa Using iPS Cells

1 citations, September 2019 in “Journal of Investigative Dermatology”

The research showed that CRISPR/Cas9 can fix mutations causing a skin disease in stem cells, which then improved skin grafts in mice, but more work on safety and efficiency is needed.

research Next Generation Human Skin Constructs as Advanced Tools for Drug Development

69 citations, June 2017 in “Experimental Biology and Medicine”

Advanced human skin models improve drug development and could replace animal testing.

research Different Polyamine Levels in the Vertex and Occipital Hair of Pattern Hair Loss Patients

September 2019 in “Journal of Investigative Dermatology”

People with pattern hair loss have higher polyamine levels in the top of their head compared to the back.

research Molecular Genetic Dissection of ILVEN Leads to Successful Targeted Therapy

September 2019 in “Journal of Investigative Dermatology”

Targeted therapy with Ustekinumab significantly improved a skin condition called ILVEN, which is caused by mutations in the CARD14 gene.

View more "xeno-free reprogramming" in research →

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community 2 months topical dutasteride plus minoxidil, very happy with the results!

in Finasteride/Dutasteride 335 upvotes 3 years ago

A user's success in treating their hair loss with 2x daily topical dutasteride and minoxidil, as well as the potential for using less frequent application of topical dutasteride due to its long half-life.

community In my opinion baldness is more prevalent now and it's being ignored..

in Chat 236 upvotes 1 year ago

The conversation is about the prevalence of baldness among young men and the potential factors contributing to it. Specific treatments mentioned include minoxidil and finasteride.