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This study found that Melamax®, originally developed as an eco-friendly hair dye, provides significant protection against ultraviolet-induced oxidative and inflammatory damage in keratinocytes by modulating gene expression and signaling pathways, highlighting its dual potential for cosmetic coloration and skin photoprotection.

This study found that chronic ultraviolet-B exposure increased skin vascularization and wrinkle formation in mice, while overexpressing the angiogenesis inhibitor thrombospondin-1 reduced these effects, suggesting angiogenesis inhibition as a potential approach to prevent photo-damage.

This study found that overexpression of PKCɛ in mouse epidermis increased sensitivity to metastatic squamous cell carcinoma, suggesting that a PKCɛ-mediated microenvironment may promote cancer development through specific cytokines like TNFα.

This study found that ultraviolet radiation causes significant damage to human hair follicles, including increased cell apoptosis and oxidative DNA damage, but this damage may be mitigated by topical caffeine.

This study found that overexpression of PKCepsilon in mouse epidermis was associated with increased susceptibility to metastatic squamous cell carcinoma, potentially through a mechanism involving tumor necrosis factor-alpha.