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research 301 Whole exome sequencing in AA patients identifies a hotspot mutation in the type II hair keratin gene, KRT82

June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that rare damaging variants in the KRT82 gene, which affect hair shaft integrity, may contribute to the risk of alopecia areata.

research Mutation analysis of type II hair keratin gene in a pedigree with monilethrix

June 2010 in “Chinese Journal of Dermatology”

This study found a novel R430Q gene mutation in hHb6, which may be linked to the hereditary hair disorder monilethrix in the examined family.

research Characterization of a 300 kbp Region of Human DNA Containing the Type II Hair Keratin Gene Domain

77 citations , March 2000 in “Journal of Investigative Dermatology”

The research identified six functional hair keratin genes and four pseudogenes, providing insights into hair formation and gene organization.

research A mutation in the type II hair keratin KRT86 gene in a Han family with monilethrix

3 citations , February 2011 in “Journal of Biomedical Research/Journal of biomedical research”

This study identified a novel mutation, R430Q in the KRT86 gene, in a Han family with monilethrix, which may contribute to the disease's pathogenic mechanism.

research A mutation in the type II hair keratin KRT86 gene in a Han family with monilethrix

3 citations , January 2011 in “生物医学研究杂志：英文版”

In this study, a novel heterozygous transition mutation in the KRT86 gene was identified, which may be pathogenic for monilethrix in a Chinese family.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Keratin

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community New Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness - Paper entitled "Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type" published journal Developmental Cell

13 upvotes 11 years ago

A new treatment using dermal sheath cup cells may regrow hair and could require repeat treatments every 8 years. Users discuss ongoing trials and plan to use finasteride and minoxidil until the treatment is available.

community I stopped finasteride and minoxidil and I regret it

in Progress Pictures 251 upvotes 4 months ago

The user regrets stopping finasteride and minoxidil due to increased hair loss. They have resumed these treatments and are considering a hair transplant.

community KX-826 1% Phase II Results from China Just Dropped

37 upvotes 1 year ago

KX-826 (Pyrilutamide) 0.5% and 1.0% solutions showed promising results in increasing hair count for male androgenetic alopecia, with the 0.5% dose slightly outperforming the 1% dose. The treatment was well-tolerated with no sexual side effects, but skepticism remains due to past inconsistencies in trial results.

community He is claiming, he can treat alopecia

in Chat 357 upvotes 8 months ago

A user claims a product can treat alopecia, but others are skeptical, calling it a scam due to lack of evidence and transparency. The product is said to inhibit Type II 5-αr by 22.9%, but is considered weaker than existing DHT blockers.

community I honestly think Dutasteride at 2.5mg could be the ultimate cure for hair loss.

in Chat 213 upvotes 1 year ago

Dutasteride at 2.5mg is considered a potential hair loss cure due to its DHT-blocking ability, but there are concerns about side effects and individual responses. Minoxidil, finasteride, and RU58841 are also discussed, with mixed opinions on their effectiveness and safety.

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