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    GlossaryThin-Layer Chromatography (TLC)

    Thin-Layer Chromatography (TLC) is a laboratory technique used to separate and identify compounds in a mixture. It involves applying a small sample to a thin layer of adsorbent material (like silica gel) coated on a glass or plastic plate. The plate is then placed in a solvent, which moves up the layer by capillary action, carrying different compounds at different rates based on their interactions with the adsorbent and the solvent. This method is widely used for analyzing the components of complex mixtures, such as in drug testing, food safety, and biochemical research.

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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
      35 M Transplant is the only way now?

      community 35 M Transplant is the only way now?

      in General  51 upvotes 21 hours ago
      A 35-year-old male has been using finasteride for 2.5 years but still finds his hair loss unsatisfactory and is considering a hair transplant. He is seeking advice on the number of grafts needed and affordable options in Canada.
      Sudden Triangular Thinning Patch

      community Sudden Triangular Thinning Patch

      in General  157 upvotes 1 week ago
      A 31-year-old has been using finasteride, dutasteride, and oral minoxidil for hair loss. They noticed a sudden triangular thinning patch on their scalp and are seeking advice, questioning if it could be medication-related.
      27M: Dutasteride and Minoxidil for Eyebrow Thinning and Hair Loss, Seeking Advice

      community 27M: Dutasteride and Minoxidil for Eyebrow Thinning and Hair Loss, Seeking Advice

      in General  183 upvotes 1 week ago
      A 27-year-old male experienced limited success with Dutasteride and topical Minoxidil for hair loss and eyebrow thinning, with side effects like decreased libido and erectile dysfunction. He is considering oral Minoxidil but is concerned about side effects, and is advised to try ketoconazole for possible dermatitis and monitor vitamin D levels.