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    GlossaryThin-Layer Chromatography (TLC)

    Thin-Layer Chromatography (TLC) is a laboratory technique used to separate and identify compounds in a mixture. It involves applying a small sample to a thin layer of adsorbent material (like silica gel) coated on a glass or plastic plate. The plate is then placed in a solvent, which moves up the layer by capillary action, carrying different compounds at different rates based on their interactions with the adsorbent and the solvent. This method is widely used for analyzing the components of complex mixtures, such as in drug testing, food safety, and biochemical research.

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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
      18M who noticed hairline retreat at 17.5

      community 18M who noticed hairline retreat at 17.5

      in General  50 upvotes 4 days ago
      An 18-year-old noticed hairline retreat at 17.5 and is seeking advice on whether to accept baldness or try treatments like Minoxidil, finasteride, or RU58841. They are concerned about safety and effectiveness at their age.
      Can this be fixed

      community Can this be fixed

      in General  16 upvotes 1 week ago
      A 24-year-old noticed hair thinning over 4-6 years and is seeking advice on whether it can be salvaged. Treatments mentioned include Minoxidil, finasteride, and RU58841.