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    GlossaryThin-Layer Chromatography (TLC)

    Thin-Layer Chromatography (TLC) is a laboratory technique used to separate and identify compounds in a mixture. It involves applying a small sample to a thin layer of adsorbent material (like silica gel) coated on a glass or plastic plate. The plate is then placed in a solvent, which moves up the layer by capillary action, carrying different compounds at different rates based on their interactions with the adsorbent and the solvent. This method is widely used for analyzing the components of complex mixtures, such as in drug testing, food safety, and biochemical research.

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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 8 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
      [M23] Finasteride journal

      community [M23] Finasteride journal

      in Journals / Progress Pictures  92 upvotes 3 days ago
      A 23-year-old male noticed hair loss and started using finasteride 1mg, initially experiencing significant shedding which reduced after 100 days. He switched from the brand Andropel to Folcres due to availability in Argentina.
      Age 22 .2nd month on finestride

      community Age 22 .2nd month on finestride

      in Journals / Progress Pictures  68 upvotes 1 week ago
      A 22-year-old is experiencing increased hair shedding and a greasy scalp after two months on 1mg finasteride. They are documenting their progress and seeking advice, with feedback suggesting that shedding is normal and results may take 6-12 months.