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Phenotypic Heterogeneity in Human Genetic Diseases: Ultrasensitivity-Mediated Threshold Effects as a Unifying Molecular Mechanism

research Phenotypic Heterogeneity in Human Genetic Diseases: Ultrasensitivity-Mediated Threshold Effects as a Unifying Molecular Mechanism

July 2023 in “Journal of Biomedical Science”

Different people show different symptoms for genetic diseases because of how sensitive their bodies are to small changes in important factors.

research Fluoroquinolone-Induced Serious, Persistent, Multisymptom Adverse Effects

39 citations, October 2015 in “Case Reports”

Some people experience severe, long-lasting side effects from fluoroquinolone antibiotics, leading to the recommendation of limited use and increased awareness of these risks.

research Betaine Supplementation Is Less Effective Than Methionine Restriction in Correcting Phenotypes of CBS Deficient Mice

19 citations, July 2015 in “Journal of inherited metabolic disease”

Methionine restriction works better than betaine for treating CBS deficiency symptoms in mice.

research Cystathionine Beta-Synthase-Deficient Mice Thrive on a Low-Methionine Diet

28 citations, November 2013 in “The FASEB journal”

Mice with CBS deficiency are healthier on a low-methionine diet.

Receiver Operating Characteristic Analysis of the Performance of Basal Serum Hormone Profiles for the Diagnosis of Polycystic Ovary Syndrome in Epidemiological Studies

research Receiver Operating Characteristic Analysis of the Performance of Basal Serum Hormone Profiles for the Diagnosis of Polycystic Ovary Syndrome in Epidemiological Studies

66 citations, November 2001 in “European journal of endocrinology”

Low SHBG and high FAI, FT, and DHEAS levels are effective in identifying PCOS.

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community Topical fin and min and swallowing semen

in Finasteride/Dutasteride 118 upvotes 5 months ago

A user asked if it's safe to swallow semen from a partner using topical finasteride and minoxidil. Responses varied, but most suggested it's likely safe, with minimal risk from small amounts of finasteride in semen.

community Transient and Permanent Effects of Finasteride Use

in Research/Science 154 upvotes 3 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community Massive study on finasteride side effects released

in Finasteride/Dutasteride 83 upvotes 1 year ago

The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

community Fin/Min/VitD 3 month progress pics

118 upvotes 5 years ago

A user shared their positive 3-month experience using finasteride, minoxidil, and vitamin D to treat hair loss, noting significant regrowth and minimal shedding. They also discussed potential side effects and the low likelihood of experiencing them, while being open to answering further questions.

community I've been afflicted by post finasteride syndrome, what now?

in Finasteride 42 upvotes 5 years ago

A user experienced severe side effects from finasteride, including mental health issues and physical symptoms, and sought advice on managing post-finasteride syndrome. Suggestions included checking vitamin levels, considering dopamine agonists, and avoiding further psychiatric medications.

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