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research Surrogate End-Points or Primary Outcomes in Clinical Trials in Women with Polycystic Ovary Syndrome?

38 citations , June 2004 in “Human Reproduction”

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

research De Novo Design of a Potent Wnt Surrogate Specific for the Frizzled7 Subtype Members

July 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

A new Wnt surrogate specifically targets the Frizzled7 receptor, promoting organoid formation and hair growth.

research Microemulsions as a Surrogate Carrier for Dermal Drug Delivery

117 citations , November 2008 in “Drug Development and Industrial Pharmacy”

Microemulsions can effectively deliver drugs through the skin but require careful ingredient selection to avoid irritation.

research Extracellular Vesicles as Surrogates for Drug Metabolism and Clearance: Promise vs. Reality

7 citations , August 2023 in “Life”

Extracellular vesicles could help tailor drug treatments, but more research is needed.

Towards a Consensus Potency Assay for Mesenchymal Stromal Cells: A Matrix Analysis of Cell Source, Donor Variability, and Inflammatory Stimuli to Refine Surrogate Markers of Immunomodulation

research Towards a Consensus Potency Assay for Mesenchymal Stromal Cells: A Matrix Analysis of Cell Source, Donor Variability, and Inflammatory Stimuli to Refine Surrogate Markers of Immunomodulation

3 citations , May 2019 in “Cytotherapy”

ATIR101 improves survival in stem cell transplant patients; Australian stem cell treatment decisions are influenced by regulation changes.

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community Another blow to the cursed baldness

in Research/Science 91 upvotes 6 months ago

A South Korean company, Therazyne, has developed a promising hair loss treatment using a WNT chain surrogate that binds to Frizzled 7, with human follicle testing expected soon. Current treatments like minoxidil and finasteride are not seen as cures, and while optimism exists for future solutions like PP405, approval processes are lengthy.

community Ketocanzole 2% has almost completely recovered my hair loss

in Ketoconazole 335 upvotes 3 months ago

Ketoconazole 2% shampoo effectively regrew hair by treating scalp dermatitis and inflammation. The user also used jojoba and oat oil, Aveeno moisturizer, and hyaluronic acid for scalp care.

community 18M 10 months on anti-androgens and oral min

in Progress Pictures 50 upvotes 2 years ago

An 18-year-old male used anti-androgens and oral Minoxidil for 10 months to treat hair loss. He initially used 1mg Finasteride and 5% topical Minoxidil for 5 months, then switched to Dutasteride for 4.5 months and inconsistently used 5mg oral Minoxidil for 2 months due to availability issues.