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      learn Neem Oil

      natural substance from Neem tree with medicinal and pesticidal properties

      learn Clascoterone

      a novel topical treatment that inhibits DHT on androgen receptors

      learn Hydrocortisone

      a synthetic cortisol used for anti-inflammatory effects

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      community Painkillers May Block Minoxidil

      in Research/Science  14 upvotes 4 months ago
      Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

      community Methods Of Staying Safe On Ru58841 - My 2 Cents

      in Research/Science  23 upvotes 6 months ago
      RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

      community 5+ year users, what has your experience been on fin and dut?

      in Chat  30 upvotes 2 weeks ago
      Users discussed their experiences with hair loss treatments, primarily finasteride (Fin) and dutasteride (Dut), often combined with minoxidil (Min) and derma rolling. Many reported mixed results, with some seeing slowed hair loss and others experiencing side effects or minimal improvement.

      community Is this broscience? From More Plates, More Dates

      in Research/Science  21 upvotes 1 year ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.