17 citations
,
September 1953 in “Journal of Cell Science” This study found that the tetrazolium salt INT is the most effective for revealing dehydrogenase activity and certain histological structures in sheep and other mammals' skin.
3 citations
,
January 2004 in “Sen i Gakkaishi” This study found that adding dithiodiglycolic acid to the hair straightening process decreased chemical damage and preserved the structural integrity of the hair matrix compared to using thioglycolic acid alone.
April 2025 in “International Journal of Cosmetic Science” This study found that using 1,4-butylenediamine bismaleimide for hair perming through thiol-Michael click chemistry offers comparable efficiency to conventional oxidative methods, with enhanced durability and reduced damage to hair fibres, preserving mechanical, color, and surface properties.
7 citations
,
July 2008 in “Experimental Dermatology” This study identified molecular elements controlling the expression and stabilization of THH protein in hair follicle cells, revealing key mechanisms that support hair shaft development in mice.
3 citations
,
August 2017 in “Synlett” This study reports a novel method for synthesizing substituted hydantoins, including the anticonvulsant drug ethotoin, using safer reagents and fewer steps compared to conventional protocols.
26 citations
,
December 2003 in “Experimental Dermatology” In this study, researchers identified two de novo germline missense mutations in the hair keratins hHb1 and hHb6 in patients with monilethrix whose parents were not clinically affected.
June 2010 in “Chinese Journal of Dermatology” This study found a novel R430Q gene mutation in hHb6, which may be linked to the hereditary hair disorder monilethrix in the examined family.
188 citations
,
June 1998 in “Molecular cell” This study found that mimicking the XPD point mutation in mice resulted in trichothiodystrophy-like symptoms, supporting the role of basal transcription and DNA repair defects in the disease.
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that deleting all three Tet genes in mice led to shorter hair shafts and altered hair types, with associated changes in gene expression and DNA hydroxymethylation.
74 citations
,
January 2006 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified novel compound heterozygous mutations in the DSG4 gene in a Japanese patient with congenital hypotrichosis, suggesting overlap between localized autosomal recessive hypotrichosis and monilethrix.
5 citations
,
July 1996 in “Journal of Cutaneous Medicine and Surgery” This study explains that while trichothiodystrophy and xeroderma pigmentosum share genetic defects, TTD patients primarily exhibit issues in transcription initiation, not the increased skin cancer risk seen in XP.
7 citations
,
March 2024 in “Non-coding RNA Research” In this study using a mouse model, researchers found that DNA methylation of the miR-365-1 promoter plays a role in reducing apoptosis in hair follicle stem cells during chemotherapeutic alopecia.
13 citations
,
April 1982 in “The Journal of Dermatology” This study found that poly(adenosine diphosphate-ribose) synthesis in human skin varies by cell type and condition, with distinct patterns in psoriatic, cancerous, and normal tissues.
29 citations
,
August 1999 in “Journal of Investigative Dermatology” New mutations in hair keratin genes cause the rare hair disorder monilethrix.
7 citations
,
March 2012 in “Journal of Investigative Dermatology” This study presents evidence that specific thymus-derived peptides affect human hair follicle growth, identifying thymulin as a potential hair growth stimulator despite interindividual response variations.
1 citations
,
January 2008 April 2012 in “Neuropediatrics” This article reviews the genetic and phenotypic characteristics of Trichothiodystrophy and discusses the associated DNA repair defects, but does not report new clinical findings.
14 citations
,
September 2016 in “Journal of Photochemistry and Photobiology B Biology” This study observed that mercury-lamp irradiation may cause cleavage of disulfide bonds in keratins of white hair, leading to the formation of thiols in laboratory settings.
71 citations
,
May 2006 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that trichothiodystrophy hair brittleness is linked to abnormalities in sulfur content and structural organization, making it prone to breakage.
6 citations
,
March 1996 in “Journal of Investigative Dermatology”
2 citations
,
April 2007 in “Journal of Labelled Compounds and Radiopharmaceuticals” This article discusses the preparation of tritium-labeled testosterone metabolites and reports no new experimental findings.
April 2023 in “Journal of Investigative Dermatology” This study found that human TMEM2 does not function as a hyaluronidase but is involved in regulating hyaluronan metabolism.
44 citations
,
March 1947 in “Endocrinology” This article reviews hair growth patterns in humans and laboratory animals, noting the random distribution of active and inactive hair follicles and differences in regional coordination among animal species, and reports no new results.
4 citations
,
October 2003 in “Annales de Génétique” This study identified a mutation in the KRTHB6 gene in two monilethrix families of Indian origin, linking specific genetic variations to different severities of hair defects within the families.
November 2012 in “Journal of Clinical Pathology” 10 citations
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July 1980 in “British Journal of Dermatology” This study observed that applying polyamines to the skin of hairless mice stimulates thymidine incorporation, suggesting polyamines may play a role in DNA synthesis control in the epidermis.
April 2018 in “Journal of Investigative Dermatology” In this study, researchers found that the NUDT15 R139C gene variant is a significant genetic risk factor for azathioprine-induced severe myelotoxicity in Japanese patients with dermatological conditions, suggesting that screening for this variant may help prevent adverse reactions in East-Asian populations.
135 citations
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October 1997 in “Journal of biological chemistry/The Journal of biological chemistry” This study suggests that trichohyalin is modified by peptidyl-arginine deiminase before being cross-linked by TGase 3, allowing the formation of rigid structures in hair follicle cells.
5 citations
,
January 2024 in “Crystals” This study characterized the crystal structures and supramolecular architectures of new salts made from 2,4-diaminopyrimidine and different dicarboxylic acids, revealing subtle differences in crystal packing and hydrogen-bonding patterns, particularly influenced by sulfur atom interactions, through Hirshfeld analysis and enrichment ratios.
September 1997 in “Clinical and Experimental Dermatology”