11 citations
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April 2023 in “Frontiers in Pharmacology” This study reported that the Computational Analysis of Novel Drug Opportunities platform effectively uses integrated biological data, including side effects and pathways, to generate potential drug candidates for colon cancer and migraine disorders.
158 citations
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January 2015 in “Artificial Intelligence in Medicine” This study found that DrugNet, a network-based prioritization method, effectively improves drug repositioning tasks, achieving high performance in validation tests and clinical trial comparisons.
This research aims to evaluate 6-month changes in total and terminal hair density, with data quality assessed using Cochrane risk of bias tools, but does not report specific study results yet.
1 citations
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October 2023 In this study, the authors found that syntax-based neural networks performed comparably to pre-trained Transformers on tasks involving definitely unseen sentences, suggesting they are a more transparent and parameter-efficient alternative for certain Natural Language Processing applications.
8 citations
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December 2022 in “Journal of Translational Medicine” This study found that the WNMFDDA model effectively predicts drug-disease associations, achieving high accuracy in cross-validation and confirming most candidate associations through existing databases.
September 2024 in “arXiv (Cornell University)” This study evaluated various NLP models for detecting bias in medical curricula, finding that fine-tuned BERT models perform well, whereas LLMs, despite being state-of-the-art in many tasks, are unsuitable for this application.
109 citations
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January 2011 in “Frontiers in Systems Neuroscience” The researchers reported that differences in brain functional connectivity between unmedicated seasonal affective disorder patients and healthy controls vary with ICA model order, peaking in volume at model order 70.
Nonlinear artificial neural networks are better at identifying different types of animal hair than linear ones.
August 2019 in “bioRxiv (Cold Spring Harbor Laboratory)” This study developed the CATNIP computational model, which uses biological and chemical information to successfully identify drug repurposing opportunities for various conditions, including Parkinson’s disease and Type 2 Diabetes.
9 citations
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June 2012 in “Joint Conference on Lexical and Computational Semantics” This study presents a system for evaluating semantic similarity between sentences by using token-based matching and improved similarity measures beyond WordNet.
4 citations
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April 2018 in “Clinical microbiology and infection” This article examines the limitations of using large databases for epidemiological research, highlighting the risk of spurious associations due to data quality issues and insufficient adjustment for multiple comparisons, and reports no new results.
This study found that a new computational method using side-effect data from social media can successfully identify known and potential new drug indications for repositioning efforts.
4 citations
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November 2023 in “ArXiv.org” This study demonstrates that a proposed multi-stage framework improves the accuracy and faithfulness of drug-related responses generated by language models, compared to traditional methods.
The researchers reported that a new computational method using side-effect data from social media effectively recovers known drug indications and identifies trial indications, suggesting utility for computational drug repositioning.
This study suggests that a novel computational method using side-effect data from social media might aid in drug repositioning by identifying known and potential therapeutic indications.
This study analyzed Reddit discussions on JAK inhibitors and found that a small number of users contribute most of the conversational content, highlighting the need for expert oversight in interpreting health information shared online.
January 2024 in “Wiadomości Lekarskie” In this study, researchers developed a novel computational framework using deep reinforcement learning to identify strategies for cellular reprogramming in gene regulatory networks, showing its effectiveness in a model of immune response against infection.
8 citations
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August 2020 in “PLOS Computational Biology” This study presents a computational approach, CATNIP, which repurposes drugs using only their biological and chemical information, predicting new uses like adrenergic uptake inhibitors for Parkinson's and vandetanib for Type 2 Diabetes.
1 citations
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September 2004 in “Physica D: Nonlinear Phenomena” This study developed a new method for analyzing multivariate time-series data that successfully predicts website competition dynamics and outperforms conventional methods in identifying and predicting competitive structures.
5 citations
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July 2019 in “Applied statistics/Journal of the Royal Statistical Society. Series C, Applied statistics” In this study, applying case-only trees and random forests to a prostate cancer prevention trial revealed genotypes that may influence the efficacy of finasteride for prostate cancer prevention.
34 citations
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January 2020 in “IEEE Access” This study reported that the PM-DBiGRU model enhances aspect-level sentiment classification in drug reviews, outperforming existing methods on the newly proposed SentiDrugs dataset.
March 2024 in “medRxiv (Cold Spring Harbor Laboratory)” This study found that faster algorithms for inferring ancestry in genomic data can better capture historical and functional insights into genome variation than traditional methods in large datasets like the UK Biobank.
January 2019 in “Figshare” This study found that intralesional corticosteroids were most likely to produce a response in mild alopecia areata, while diphenylcyclopropenone was top-ranked for moderate to severe cases.
2 citations
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April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study introduced a statistical method, PLACO, which revealed novel genetic regions associated with both Type 2 Diabetes and Prostate Cancer from GWAS data.
This study developed a computational method using side-effect data from social media to identify potential new drug indications, showing that it successfully recovered known and trial indications.
3 citations
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November 2022 in “European Journal of Human Genetics” This study developed new genetic prediction models for male pattern baldness with improved accuracy by utilizing a large set of markers and independent datasets, making them the most reliable available for this trait.
This study suggests that using a new computational method to mine social media for side-effect data may enhance drug repositioning by recovering known and trial drug indications effectively.