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Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research Physiological and Retinoid-Induced Proliferations of Epidermis Basal Keratinocytes Are Differently Controlled

127 citations , July 2002 in “EMBO journal”

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

research Alpha-Mangostin, a Safe and Natural Product as a Candidate Skin-Whitening Agent

December 2025 in “Scientific Reports”

α-Mangostin can naturally lighten skin by reducing melanin.

research Genetic Dissection of Retinoic Acid Function in Epidermis Physiology

9 citations , May 2002 in “PubMed”

Retinoic acid affects skin and hair health by working with specific receptors, and its absence can lead to hair loss and skin changes.

research Stem Cells Tightly Regulate Dead Cell Clearance to Maintain Tissue Fitness

2 citations , May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Stem cells help remove dead cells to keep tissues healthy by balancing cell replacement and clearance.

View more "rar rxr heterodimer" in research →

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community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 7 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community Is tazarotene potentially better than tretinoin in combination with topical minoxidil?

in Chat 1 upvotes 2 months ago

Tazarotene may be more effective than tretinoin when combined with topical minoxidil for hair loss due to its selective binding to RAR-beta and gamma, though it can cause irritation. Tazarotene's potency can lead to indirect inflammatory reactions despite potentially causing less irritation than tretinoin.

community Tazarotene better than Tretinoin with minoxidil?

in Chat 9 upvotes 1 year ago

Switching from tretinoin to tazarotene with minoxidil led to new hair regrowth after years of maintenance. Tazarotene's selectivity and higher concentration might be more effective for hair growth.

community Tazarotene shows strong standalone hair regrowth potential, not just a Minoxidil enhancer. Backed by VEGF, HF regeneration, and angiogenesis pathways. Here’s why.

in Research/Science 137 upvotes 6 months ago

Tazarotene shows potential as a standalone treatment for hair regrowth by stimulating new hair follicle formation and promoting angiogenesis, similar to microneedling effects. It can be used topically without minoxidil, but users should start with a low concentration to avoid irritation.

community Minoxidil works only with Retinoic acid

in Minoxidil 320 upvotes 6 months ago

Minoxidil is more effective when combined with retinoic acid, such as tretinoin or tazarotene, enhancing hair growth. Some users experience significant regrowth, while others see minimal effects or side effects.