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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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research compound made to degrade androgen receptors in scalp
Research
5 / 944 resultsresearch Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome
Changes in the SREBF1 gene cause a rare genetic skin and hair disorder.
research The Role of Astrotactin2 in Regulating Mammalian Skin Polarity
Astrotactin2 affects hair follicle orientation and skin cell polarity.
research Matriptase: Potent Proteolysis on the Cell Surface
Matriptase was a type II transmembrane serine protease crucial for epidermal barrier function, hair follicle growth, and thymocyte survival. Its activation involved complex proteolytic cleavages and interaction with the inhibitor HAI-1. Matriptase-deficient mice showed severe defects in epidermal barrier, hair growth, and increased thymocyte apoptosis, leading to perinatal mortality. Dysregulation of matriptase and HAI expression was linked to human cancers, with unopposed matriptase promoting carcinogenesis and metastasis in animal models. While matriptase was consistently expressed in various epithelial tumors, its expression varied across cancers, complicating its use as a prognostic marker. Inhibition of matriptase impaired tumor cell invasion, highlighting its role in malignant progression. Despite advances, many questions about its precise functions and mechanisms remained unanswered.
research Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway
Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.
research Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin
Prostasin has two roles in skin: one for normal skin development without needing activation, and another for proper hair growth that requires activation.
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4 / 4 resultscommunity GT20029 China Phase II Trial For AGA Reached Primary Endpoint
The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.
community Q1 2024 is done. And kintor is completely silent about GT20029.
The conversation discusses the lack of updates on GT20029 for hair loss treatment, with some users noting recent reports indicating ongoing data collection. There are mentions of other treatments like Pyrilutamide and Minoxidil.
community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment
The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.
community Is GT20029 supposed to regrow hair as well?
The user is considering switching from finasteride to dutasteride for hair loss. They are unsure if GT20029 can regrow hair, particularly on the temples. Another user mentions that regrowth on finasteride can take up to 2 years.