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GlossaryPostmenopausal

stage after 12 months without a menstrual period

Postmenopausal refers to the stage in a woman's life that occurs after she has experienced 12 consecutive months without a menstrual period, marking the end of her reproductive years. This phase typically begins in women between the ages of 45 and 55 and is characterized by a decrease in the production of hormones such as estrogen and progesterone, which can lead to various physiological changes and symptoms, including hot flashes, osteoporosis, and changes in hair and skin.

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research Stromal Cells of the Human Postmenopausal Ovary Display a Distinctive Biochemical and Molecular Phenotype

June 2003 in “Obstetrical & Gynecological Survey”

Postmenopausal ovary stromal cells have a unique makeup and limited steroid production, suggesting androgens come from the adrenal gland.

research Approach to Investigation of Hyperandrogenism in a Postmenopausal Woman

November 2022 in “The Journal of Clinical Endocrinology and Metabolism”

Postmenopausal hyperandrogenism, a condition with symptoms like increased hair growth and acne, is usually caused by PCOS but can also be due to other factors. It's diagnosed by checking testosterone levels and treated either by removing the adrenal tumor or through antiandrogen therapy.

research Postmenopausal Alopecia Due to Ovarian Hyperandrogenemia Treated With Bilateral Salpingo-Oophorectomy

January 2020 in “Journal of South Asian Federation of Obstetrics and Gynaecology”

Removing the ovaries can help treat hair loss caused by high androgen levels in postmenopausal women.

research Gonadotropin-Releasing Hormone Agonist Treatment in Postmenopausal Women with Hyperandrogenism of Ovarian Origin

36 citations , May 2011 in “The Journal of Clinical Endocrinology & Metabolism”

Treatment with a hormone agonist can reduce excess male hormones in postmenopausal women without surgery.

research Bilateral Leydig Cell Hyperplasia: A Rare Cause of Postmenopausal Hirsutism

1 citations , February 2022 in “Case reports in endocrinology”

An unusual growth of Leydig cells in a woman's ovaries caused her excessive hair growth, which was treated successfully with surgery.

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community No, Finasteride as a treatment for MPB was not an "accident"

in Research/Science 106 upvotes 4 years ago

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

community 24 y/o woman diagnosed with AGA today. Scared and confused.

9 upvotes 9 years ago

A 24-year-old woman being diagnosed with androgenic alopecia (AGA) who is scared and confused about her hair loss, and the treatment options of Minoxidil, finasteride, RU58841, spironolactone, and possibly a biopsy.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Losing Hair on Dutasteride? You might have LPP

in Research/Science 94 upvotes 1 year ago

Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 1 year ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

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