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research Loss of PIKFyve Kinase Function Driven by Platelet Factor 4 Promoter Results in Platelet Lysosomal Storage Defects and Infiltration of Multiple Organs with Vacuolated Macrophages

November 2011 in “Blood”

PIKFyve is essential for normal platelet function and its deficiency causes organ issues and macrophage infiltration.

research The Complex Relationship Between TFEB Transcription Factor Phosphorylation and Subcellular Localization

344 citations , May 2018 in “EMBO journal”

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

research Role of Endolysosomes in Severe Acute Respiratory Syndrome Coronavirus-2 Infection and Coronavirus Disease 2019 Pathogenesis: Implications for Potential Treatments

55 citations , October 2020 in “Frontiers in Pharmacology”

Targeting endolysosomes may help treat COVID-19.

research Host-Directed FDA-Approved Drugs with Antiviral Activity Against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods

42 citations , April 2021 in “Pharmaceuticals”

Five FDA-approved drugs may help block COVID-19 virus entry.

The Need for Speed and Efficiency: A Brief Review of Small Molecule Antivirals for COVID-19

research The Need for Speed and Efficiency: A Brief Review of Small Molecule Antivirals for COVID-19

6 citations , March 2022 in “Frontiers in drug discovery”

Some small molecule antivirals show promise against COVID-19, but more research is needed to understand and improve them.

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