This study found that testosterone enhances glucose-stimulated insulin secretion in male and female human islets through its conversion to DHT and E2, a process disrupted by 5α-reductase and aromatase inhibitors.
This study found that testosterone enhances glucose-stimulated insulin secretion in male and female human islets, requiring conversion to DHT and E2 via SRD5A1 and aromatase.
March 2020 in “The Thai Journal of Veterinary Medicine”
This case report describes the occurrence of juvenile diabetes mellitus with concurrent exocrine pancreatic insufficiency in a Thai Bangkaew dog, highlighting its successful management with insulin, pancreatic enzymes, and methylcobalamin.
31 citations
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January 2017 in “Advances in Experimental Medicine and Biology”
This review discusses the negative health impacts of testosterone deficiency and the potential adverse effects of 5α-reductase inhibitors, emphasizing the need for patient-physician discussions regarding these treatments.
Baldness is not an evolutionary disadvantage because it occurs after reproductive age. Treatments like Minoxidil and Finasteride are used for androgenetic alopecia but don't address the root cause.