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Solute binding to hair keratin is mainly driven by hydrophobic interactions and changes with pH.

Some psychiatric medications can cause hair loss, but it usually grows back after adjusting the medication.

Antidepressants may improve or resolve scalp dysesthesia in most patients.

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

Skin reactions to antidepressants are common but usually not serious and can be treated.