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This case report describes a man diagnosed with Hoffman syndrome, characterized by muscle hypertrophy and weakness due to severe hypothyroidism, who had an excellent response to thyroid hormone replacement.

This case report highlights that in severe illnesses like sepsis, myxedema coma can occur with less elevated TSH levels than typical for primary hypothyroidism, likely due to inflammatory cytokines affecting TSH secretion, even when central lesions are absent.

This veterinary case study of a dog with myxedema coma found clinical and pathologic changes including severe thyroid atrophy and marked atherosclerosis consistent with the diagnosis.

This case report describes a rare and atypical presentation of primary hypothyroidism with myxedema in a two-year-old boy, highlighting the importance of recognizing unusual symptoms for timely treatment.

This case report describes an unusual instance of myxedema in a woman with severe hypothyroidism, presenting with skin findings in atypical locations and improvement following levothyroxine treatment.