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GlossaryMHC class I (MHC-I)

present protein fragments to cytotoxic T cells for immune response

MHC class I, or Major Histocompatibility Complex class I, are molecules found on the surface of almost all nucleated cells in the body. They play a crucial role in the immune system by presenting small fragments of proteins (peptides) from inside the cell to cytotoxic T cells. This helps the immune system recognize and destroy infected or cancerous cells.

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Diphencyprone and Topical Tacrolimus as Two Topical Immunotherapeutic Modalities: Are They Effective in the Treatment of Alopecia Areata Among Egyptian Patients? A Study Using CD4, CD8, and MHC II as Markers

research Diphencyprone and Topical Tacrolimus as Two Topical Immunotherapeutic Modalities: Are They Effective in the Treatment of Alopecia Areata Among Egyptian Patients? A Study Using CD4, CD8, and MHC II as Markers

13 citations , June 2010 in “Journal of dermatological treatment”

Diphencyprone is effective for treating patchy hair loss in alopecia areata, but tacrolimus is not.

T-Cell Induced-Self MHC Class I/Peptide Complexes May Enable De Novo Tolerance Induction to Neo-Antigens Occurring Outside of the Thymus

research T-Cell Induced-Self MHC Class I/Peptide Complexes May Enable De Novo Tolerance Induction to Neo-Antigens Occurring Outside of the Thymus

8 citations , October 2016 in “Experimental dermatology”

Hair follicles may help teach the immune system to tolerate new self-antigens, but this can sometimes cause hair loss.

research Transplantation Immunology: Solid Organ and Bone Marrow

139 citations , February 2010 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Transplant success has improved with better immunosuppressive drugs and donor matching.

research Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege

47 citations , December 2011 in “Experimental Dermatology”

CGRP may help protect hair follicles from immune system attacks, potentially slowing hair loss.

research SOCS3 Treatment Prevents the Development of Alopecia Areata by Inhibiting CD8+ T Cell-Mediated Autoimmune Destruction

16 citations , March 2017 in “Oncotarget”

SOCS3 treatment can prevent hair loss by stopping harmful immune responses.

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