research Insights Learned from L457(3.43)R, an Activating Mutant of the Human Lutropin Receptor 17 citations, October 2006 in “Molecular and Cellular Endocrinology” The L457(3.43)R mutation in the human lutropin receptor causes increased activity and hormone insensitivity, leading to precocious puberty.
research Spontaneous Fertility in a Male Patient with Testotoxicosis Despite Suppression of FSH Levels 3 citations, February 2018 in “Human Reproduction” A man with testotoxicosis was fertile despite low FSH levels, suggesting high testosterone may allow sperm production without FSH.