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Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations, September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research Does Inhibition of Aldose Reductase Contribute to the Anti-Inflammatory Action of Setipiprant?

6 citations, August 2017 in “Physiological Research”

Setipiprant may reduce inflammation by blocking an enzyme called aldose reductase.

research Sulphation Catalyzed by the Human Cytosolic Sulphotransferases: Chemical Defense or Molecular Terrorism?

48 citations, July 1996 in “Human & Experimental Toxicology”

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

research The Pharmaceutical Market as Reflected by Patents

December 2011 in “Drug Research”

The document shows the state of pharmaceutical patents as of 1999, focusing on treatments for various diseases.

research Phenolsulphotransferase: Localization in Kidney During Human Embryonic and Fetal Development

18 citations, November 1994 in “Histochemical Journal”

The enzyme PST is found in developing human kidneys and helps with detoxification and development.

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community Interpreting pre-finisteride blood panels

in Chat 2 upvotes 1 week ago

The conversation is about someone planning to start finasteride for hair loss and wanting to interpret pre-treatment blood panels to assess the risk of side effects like gynecomastia. They list various tests to measure hormone levels and other health indicators.

community Pre-Finisteride DHT & Hormone Blood Panel

in Finasteride/Dutasteride 3 upvotes 3 weeks ago

The conversation discusses the cost and insurance coverage of a comprehensive hormone and DHT blood panel for hair loss, with a focus on finasteride treatment. The user seeks a cheaper alternative to a $700 panel recommended in a video.

community Dutasteride 1mg or RU58841 8% or topical Dutasteride

in Treatment 3 upvotes 1 week ago

The discussion focuses on hair loss treatments, with suggestions to increase oral Dutasteride to 1 mg or more, as topical Dutasteride is less effective. Other treatments mentioned include RU58841, Minoxidil, and dermastamping, with some users recommending injectable mesotherapy and topical Finasteride.

community 6 Month Progress Pics - Dutasteride

in Progress Pictures 140 upvotes 1 year ago

The conversation discusses hair loss and the use of Dutasteride for treatment. One participant strongly supports the use of Dutasteride.

community Help needed with finding an alternative to my dermatologist's recommendation ( shampoo and conditioner)

6 years ago

A user is seeking alternatives to **Curatio Triclenz Hair Cleanser** and **Triflow Hair Conditioner** due to issues with hair weight and scalp pimples. They need recommendations for mild shampoos available in Europe, preferably Sweden.

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