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Hypothalamic-Pituitary-Adrenal Axis

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research Sex Differences in the Hypothalamic–Pituitary–Adrenal Axis’ Response to Stress: An Important Role for Gonadal Hormones

197 citations , January 2019 in “Neuropsychopharmacology”

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

research Alopecia Areata: Hyperactivity of the Hypothalamic–Pituitary–Adrenal Axis Is a Myth?

5 citations , May 2017 in “Journal of the European Academy of Dermatology and Venereology”

The study found no significant difference in stress hormone levels between people with alopecia areata and healthy individuals, suggesting that the disease is not caused by an overactive stress response system.

research Central 5-Alpha Reduction of Testosterone Is Required for Testosterone's Inhibition of the Hypothalamo-Pituitary-Adrenal Axis Response to Restraint Stress in Adult Male Rats

51 citations , July 2013 in “Brain Research”

Testosterone needs to be converted to DHT to reduce stress response in male rats.

research Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA-A Receptors

248 citations , December 2011 in “Journal of Neuroscience”

Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.

research Alcohol Exposure During Late Adolescence Increases Drinking in Adult Wistar Rats, an Effect That Is Not Reduced by Finasteride

12 citations , September 2012 in “Alcohol and Alcoholism”

Alcohol in teen years leads to more adult drinking, finasteride doesn't help.

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community How to reduce cortisol (stress hormone) naturally?

in Chat 38 upvotes 3 years ago

The conversation discusses natural ways to reduce cortisol, such as avoiding caffeine, getting proper sleep, syncing with the sun, walking in nature, breathing exercises, increasing calories, and not doing keto. Magnesium supplements are recommended for stress reduction.

community CB-03-01 / Breezula Personal Results

in Treatment 15 upvotes 2 weeks ago

The user shared their experience with CB-03-01 (Breezula/Clascoterone) for hair loss, noting reduced shedding and improved hair appearance but experiencing significant sleep disturbances and low energy due to HPA axis suppression. They decided to stop using it due to these side effects and are waiting for GT20029 as an alternative.

community EMA is re-examining Winlevi (clascoterone at lower concentration)

in Treatment 8 upvotes 7 months ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community There’s actually a quite good chance that next year, we might see a new treatment get FDA approval for the first time in nearly three decades.

in Research/Science 81 upvotes 1 year ago

Breezula, a potential new hair loss treatment, may receive FDA approval soon, but it is expected to be a weaker alternative to finasteride and minoxidil. Concerns include its twice-daily application and possible side effects like HPA axis suppression.

community Is hydrocortisone that bad for your scalp?

in Minoxidil 1 upvotes 1 year ago

Hydrocortisone is not recommended for long-term use on the scalp due to potential side effects like thinning and steroid-related issues. Alternatives like foam minoxidil or oral minoxidil are suggested, though foam may be less effective.

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