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Iron deficiency causes hair loss by affecting hair differentiation and cycling.

This study found that maternal hephaestin knockout in mice leads to neonatal hair loss, likely due to low iron levels in the mother's milk.

This study found that knockout mice lacking intestinal hephaestin are smaller and anemic compared to wild-type, suggesting other mechanisms may compensate for iron absorption.

This study reports that compound heterozygous loss-of-function mutations in the HEPHL1 gene in a child were associated with abnormal hair and cognitive issues, linking altered ferroxidase activity to hair disorders.

This study in mice found that maternal iron deficiency led to hair loss and growth abnormalities in offspring due to increased oxidative stress and disrupted signaling pathways, but postnatal iron supplementation was able to reverse these effects.