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GlossaryRegulatory Network (GRN)

interactions controlling gene expression within a cell

A Regulatory Network, often referred to as a Gene Regulatory Network (GRN), is a complex system of interactions between genes, proteins, and other molecules that control the expression levels of genes within a cell. These networks are crucial for determining how cells respond to various signals and environmental conditions, ultimately influencing processes like development, differentiation, and disease.

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research Exome-Wide Age-Of-Onset Analysis Reveals Exonic Variants In ERN1 And SPPL2C Associated With Alzheimer’s Disease

12 citations, February 2021 in “Translational Psychiatry”

Researchers found two new genetic variants linked to Alzheimer's disease.

research RSL4 Regulatory Network Acts as an Early Driver of Root Hair Growth at Low Temperature in Arabidopsis Thaliana

April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

A gene network led by RSL4 is crucial for early root hair growth in response to cold in Arabidopsis thaliana.

research Developmental Mechanisms Controlling Cell Fate Evolution

January 2016 in “Elsevier eBooks”

The conclusion is that grasping how cells determine their roles through evolution is key, with expected progress from new research models and genome editing.

research New Frontiers in CRISPR/Cas9 Delivery Systems for Gene Editing

June 2022 in “Authorea (Authorea)”

Efficient delivery systems are needed for the clinical use of CRISPR-Cas9 gene editing.

research Exome-Wide Age-of-Onset Analysis Reveals Exonic Variants in ERN1, TACR3, and SPPL2C Associated with Alzheimer’s Disease

January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Certain genetic variants in ERN1, TACR3, and SPPL2C are linked to when Alzheimer's disease starts.

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