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Did you mean Feminizing Hormone Therapy?

Glossary Feminizing Hormone Therapy

involves estrogen and anti-androgens to induce female secondary sexual characteristics

Feminizing Hormone Therapy, also known as Hormone Replacement Therapy (HRT) for transgender women, involves the administration of estrogen and anti-androgens to induce physical changes that align an individual's secondary sexual characteristics with their gender identity. This therapy can lead to breast development, redistribution of body fat, reduced muscle mass, and decreased body hair growth, among other changes.

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Research

5 / 260 results

research Navigating the Intersection of Hormonal Therapy and Acne Management in Trans Youth

January 2025 in “ARC Journal of Dermatology”

This study discusses the importance of careful dermatological care for transgender youth receiving hormonal therapies, cautioning that acne treatments can interfere with hormone replacement therapy and emphasizing the need for a collaborative interdisciplinary approach to support both acne management and overall well-being.

research Review of the effects of 17α-estradiol in humans: a less feminizing estrogen with neuroprotective potential

26 citations , February 2009 in “Drug Development Research”

This article reviews the potential neuroprotective effects of 17α‐estradiol in neurodegenerative diseases and highlights its possibly lower toxicity compared to more feminizing hormones, but it reports no new clinical findings.

research The Impact of Gender Affirming Hormone Therapy on Physical Performance

July 2023 in “The Journal of Clinical Endocrinology and Metabolism”

This narrative review suggests that, after at least two years of gender-affirming hormone therapy, nonathletic transgender individuals tend to have physical performance levels similar to cisgender individuals, though more controlled research is necessary, particularly among trans athletes.

Transgender and Migraine: Impact of Hormone Therapy

research Transgender and Migraine

7 citations , January 2019 in “Headache”

This source suggests that migraine prevalence increases in transgender women using oestrogen and decreases in transgender men using testosterone, with high oral oestrogen doses in transgender women potentially linked to aura risk.

research Dermatologic Care of Hair in Transgender Patients: A Systematic Review of Literature

4 citations , July 2021 in “Dermatology and therapy”

This review examines changes in hair physiology and treatment options for transgender patients on hormonal therapy but reports no new clinical findings, offering treatment recommendations based on the authors' experiences.

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Community Join

5 / 71 results

community (MTF 35) Results of 18 Months of HRT

775 upvotes 8 months ago

A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.

community Transplant Candidate? (26, Male)

40 upvotes 8 months ago

A 26-year-old male considering a hair transplant is using topical finasteride and minoxidil, planning to start feminizing hormone replacement therapy (HRT) with estrogen and spironolactone. Many suggest waiting to see the effects of HRT, which may significantly regrow hair, before deciding on a transplant, and recommend adding microneedling and possibly switching to oral treatments for better results.

community Feminizing Hormons wet through the roof with Finasterid

29 upvotes 1 month ago

A user experienced increased estrogen levels after 11 months on finasteride, leading to concerns about feminizing effects. They plan to reduce the finasteride dosage and consider using an aromatase inhibitor to manage estrogen levels.

community 2.5 years Minoxidil and HRT, CPA->Lupron +Minox 5%

in Transgender 611 upvotes 1 year ago

The user experienced significant hair regrowth after 2.5 years of using Minoxidil 5% and hormone replacement therapy (HRT) with Lupron, despite initial scalp irritation. Finasteride was ineffective for them.

community 4 months 5mg oral min. 3 months 1.25 mg fin. 3 months dermarolling 1x per week. 3 months Hrt.

in Is this regrowth? 15 upvotes 1 year ago

The conversation discusses hair regrowth using 5mg oral Minoxidil, 1.25mg Finasteride, weekly dermarolling, and hormone replacement therapy (HRT) with estrogen and testosterone blockers. The user reports positive results and attributes significant improvement to HRT.

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Learn

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learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

learn Estradiol

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol helps treat hair loss by balancing hormones and supporting hair follicle health.

learn Follistatin

Is follistatin safe for use in women or transgender individuals undergoing hormone therapy? No study has tested follistatin in women or transgender people on hormone therapy, and it has no approved human use or established dose; the one relevant signal, from a 2023 randomized study in adolescents with PCOS, links higher follistatin to less favourable metabolic markers, so the published evidence does not support using it in this group.

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