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25 Years of Estrogen Receptor Beta: A Personal Journey

research 25 years of ERβ: a personal journey

11 citations , September 2021 in “Journal of molecular endocrinology”

This review discusses differences in ERβ signaling between rodents and humans and reports no new clinical results; the authors highlight the need for further research in humans before using ERβ agonists clinically.

research Minoxidil May be a Partial Agonist of Estrogen Receptor Alpha

April 2026 in “microPublication”

In this study, researchers explored whether minoxidil, a common treatment for androgenetic alopecia, may have estrogenic activity and found preliminary evidence suggesting it could act as a partial agonist of Estrogen Receptor α (ERα).

Pharmacological Activation of Estrogen Receptors-α and -β Differentially Modulates Keratinocyte Differentiation with Functional Impact on Wound Healing

research Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing

23 citations , September 2015 in “International Journal of Molecular Medicine”

This study found that the activation of ER‑β increased keratinocyte proliferation and gene expression related to epidermal regeneration, enhancing wound healing in both cell models and rats.

research Estrogen Receptor α, but not Estrogen Receptor β, is Involved in the Regulation of the Hair Follicle Cycling as well as the Thickness of Epidermis in Male Mice

72 citations , November 2002 in “Journal of Investigative Dermatology”

Estrogen receptor α controls hair growth cycles and skin thickness in male mice.

research Sex Hormones: Hormonal Contraception and Hormone Replacement Therapy

2 citations , January 2019

Hormonal contraceptives and therapies regulate organ functions and treat various conditions.

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community Do essential oils help promote hair regrowth along the hairline combined with 1.0 mm dermarolling? (I am on finasteride)

6 upvotes 7 years ago

Essential oils combined with dermarolling may not significantly promote hair regrowth along the hairline. Minoxidil and finasteride are more commonly used, with minoxidil potentially causing initial hair shedding.

community Positive Hair Result in Patient using Tirzepatide

4 upvotes 1 year ago

A 57-year-old man with male pattern hair loss and insulin resistance experienced hair regrowth and weight loss after using tirzepatide, without other hair treatments. Dysregulated glucose metabolism is linked to hair loss, with tirzepatide potentially improving hair density by normalizing insulin resistance.

community Theoretical Solution to 5AR inhibition driven hard flaccid

1 upvotes 3 weeks ago

The user experienced a rare side effect, "hard flaccid," from finasteride and explored a solution involving Guanfacine and Doxazosin to manage norepinephrine levels and smooth muscle spasms. They suggest this protocol, along with reverse kegel exercises, may help others with similar symptoms.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community PP405 (Everychem 3HP) Anecdotes - Please assemble and share your story

in Chat 107 upvotes 5 months ago

PP405 (Everychem 3HP) may help with hair regrowth, with mixed user experiences. Users often combine it with minoxidil and finasteride, but there are concerns about its efficacy and side effects.

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