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Electron Paramagnetic Resonance Spectroscopy for Investigating Murine Telogen Skin After Spontaneous or Depilation-Induced Hair Growth

research Electron Paramagnetic Resonance Spectroscopy for Investigating Murine Telogen Skin After Spontaneous or Depilation-Induced Hair Growth

22 citations, February 2008 in “Journal of Dermatological Science”

EPR spectroscopy showed that spontaneous hair growth results in thicker skin and less pigmented hair than depilation-induced growth.

Investigation of the Cutaneous Penetration Behavior of Dexamethasone Loaded to Nano-Sized Lipid Particles by EPR Spectroscopy, and Confocal Raman and Laser Scanning Microscopy

research Investigation of the Cutaneous Penetration Behavior of Dexamethasone Loaded to Nano-Sized Lipid Particles by EPR Spectroscopy, and Confocal Raman and Laser Scanning Microscopy

21 citations, December 2016 in “European journal of pharmaceutics and biopharmaceutics”

Nano-sized lipid particles increase dexamethasone's skin penetration and create a reservoir in the skin layers.

research Discovery of a Novel Hybrid from Finasteride and Epristeride as 5α-Reductase Inhibitor

18 citations, January 2011 in “Bioorganic & Medicinal Chemistry Letters”

New hybrid compound found to effectively prevent hair loss.

research The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo

17 citations, April 2016 in “Journal of Investigative Dermatology”

KB2115 (eprotirome) can safely extend the hair growth phase without damaging cells or changing hair color.

research Characterization of Hair Lipid and Protein Dynamics Using EPR Spectroscopy and Treatment Effects

December 2023 in “Journal of molecular structure”

Hair treatments and dehydration affect hair's lipid and protein behavior, influencing its flexibility and appearance.

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community FCE 28260: A Forgotten 5α-Reductase Inhibitor

in Research 330 upvotes 2 months ago

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

community How significant is the difference between 0.5mg Dut and 1mg Fin?

in Finasteride/Dutasteride 11 upvotes 5 months ago

0.5mg dutasteride reduces scalp DHT more than 1mg finasteride, leading to better hair regrowth results. Users report significant improvement with dutasteride compared to finasteride.

community New Hair Loss Treatment from Kintor Just Hit the Market: KX-826!

in Product 38 upvotes 4 months ago

Kintor Pharmaceutical's new hair loss treatment, KX-826, is entering the market. Users are eager to see its effectiveness before celebrating.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.