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research Exploring the neural mechanisms of finasteride: a proteomic analysis in the nucleus accumbens

14 citations , October 2016 in “Psychoneuroendocrinology”

This study identified significant changes in the expression of nine proteins in the nucleus accumbens of rats treated with finasteride, suggesting potential novel targets for its neuropsychiatric effects.

research Coat Color in Intact and Neurointermediate Lobe-Grafted Agouti Mice: Effect of Dopamine Agonists and Antagonists

4 citations , January 1982 in “Neuroendocrinology”

This study found that pimozide, d-butaclamol, and pituitary pars intermedia grafts darken hair color in agouti C3H Avy mice, suggesting dopaminergic inhibition influences peptide-controlled hair color cycling.

research The connection of 5-alpha reductase inhibitors to the development of depression

4 citations , August 2021 in “Biomedicine & Pharmacotherapy”

This review summarizes the association between 5-alpha reductase inhibitors and depression, discussing potential mechanisms such as neuroactive steroid alterations and neuroinflammation, but reports no new clinical results.

research A second case of effective eradication of alopecia areata following treatment with the dopaminergic drug dextroamphetamine

April 2025 in “International Journal of Clinical & Medical Case Studies”

This source explains that unlike genetic hormonal alopecia, alopecia areata is associated with inflammatory factors and may also involve psychological and genetic contributions.

research Inhibition of 17α-hydroxylase/C17,20 lyase reduces gating deficits consequent to dopaminergic activation

19 citations , September 2013 in “Psychoneuroendocrinology”

Blocking CYP17A1 enzyme may help improve certain brain function issues related to dopamine.

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community Any finasteride users have a history of depression?

in Finasteride/Dutasteride 26 upvotes 2 years ago

The conversation discusses finasteride for hair loss, especially among those with a history of depression. Users shared mixed experiences, with some reporting no issues and others experiencing worsened depression.

community How is dht not beneficial to you?

in Finasteride/Dutasteride 111 upvotes 7 months ago

DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

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