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Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations, September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research Recent Advances in Thiasteroids Chemistry

37 citations, October 2006 in “Steroids”

New sulfur-containing steroid analogs show promise for more targeted medical treatments.

research Lignans and Neolignans: Plant Secondary Metabolites as a Reservoir of Biologically Active Substances

112 citations, May 2019 in “Pharmacological Research”

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

research Current Status of Genus Impatiens: Bioactive Compounds and Natural Pigments with Health Benefits

11 citations, February 2021 in “Trends in Food Science and Technology”

Impatiens plants have health-promoting compounds and are used for natural food coloring, but more research is needed to understand their full benefits.

research Vitamin D-Dependent Rickets Type II: Extreme End Organ Resistance to 1,25-Dihydroxy Vitamin D3 in a Patient Without Alopecia

50 citations, October 1986 in “European journal of pediatrics”

A boy with severe Vitamin D-resistant rickets did not respond to treatment and lacked a common symptom, suggesting a need for alternative treatments.

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community Pure Curiosity: Effects of increased testosterone blood levels because of Finasteride?

in Finasteride 6 upvotes 5 years ago

Finasteride may have positive effects by keeping testosterone levels higher, potentially maintaining youthfulness and physical performance as one ages. It could also help with conditions related to aging like andropause and sarcopenia without increasing estradiol levels.

community Minoxidil + Gym + Cutting. Is it bad?

in Minoxidil 38 upvotes 1 year ago

A user is concerned about weight loss stagnation while using minoxidil and finasteride during a calorie-cutting diet. Responses suggest water retention or a weight loss plateau as possible causes.

community Dutasteride causing us to have… girl babies?

in Finasteride/Dutasteride 26 upvotes 1 year ago

User Kylo313 used dutasteride for 20 years and had two daughters, questioning if dutasteride affects the likelihood of having male vs female children. Replies mostly request hairline photos and discuss anecdotal experiences, with some suggesting correlation doesn't imply causation and that gender determination isn't affected by dutasteride.