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research Dependence of anxiolytic effects of the dipeptide TSPO ligand GD-23 on neurosteroid biosynthesis

6 citations , July 2016 in “Doklady Biochemistry and Biophysics”

This study found that GD-23, a dipeptide ligand of TSPO, exhibited an anxiolytic effect in the elevated plus maze test, which was inhibited by selective neurosteroid synthesis inhibitors, suggesting a neurosteroidogenic mechanism.

research Nerve dependence in tissue, organ, and appendage regeneration

228 citations , September 2012 in “Trends in Neurosciences”

This review examines the role of nerves in regeneration across various species and discusses their importance as components in the progenitor cell niche, reporting no new clinical results.

research Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR.

122 citations , June 1998 in “PubMed”

This study found that sensory and sympathetic innervation in the mystacial pads of mice is governed by a balance of neurotrophin signaling, highlighting the roles of NGF/trkA and NT-3/trkC pathways.

research Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity

28 citations , July 2008 in “Developmental Biology”

This study found that the loss of Smad4 in keratinocytes reduces Dsg4 expression via disrupted BMP signaling, contributing to hair follicle degeneration and alopecia.

research State-dependent signaling by Ca_v1.2 regulates hair follicle stem cell function

27 citations , June 2013 in “Genes & development”

This study found that L-type channel blockers can induce hair growth in Timothy syndrome by overcoming delays in anagen phase, suggesting a potential therapeutic role for tissue regeneration.

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community How dependent will my other hairs get on minoxidil?

in Minoxidil 12 upvotes 1 year ago

A user is starting a finasteride and minoxidil routine for diffuse pattern hair loss and is concerned about hair dependency on minoxidil. Responses suggest that new hairs may not survive without minoxidil, but existing hairs won't fall out if minoxidil is stopped, though experiences vary.

community Does hair become dependent on latanoprost like it does with minoxidil?

4 upvotes 6 months ago

The conversation discusses the use of 0.1% latanoprost for hair regrowth, with concerns about cost and dependency. The user currently uses dutasteride and oral minoxidil and is considering adding latanoprost to their regimen.

community The dose dependent nature of the cardiac effects RU58841

5 upvotes 8 months ago

Reducing the dose of RU58841 from 25mg to 7.5mg topically helped minimize heart palpitations. Users discussed the cardiac effects of RU58841 and minoxidil, noting that no treatment is completely free of side effects.

community Since Dutasteride is dose dependent, is there any real difference in taking 0.5mg daily vs every other day?

in Finasteride/Dutasteride 16 upvotes 1 year ago

Taking dutasteride daily at higher doses results in more effective DHT suppression compared to every other day dosing, due to its dose-dependent nature and long half-life. Even at lower doses, dutasteride is more effective than finasteride for hair loss.

community Aminexil, Nanoxidil, Stemoxydine and Kopexil. Anyone use them?

1 upvotes 9 years ago

Aminexil, nanoxidil, stemoxydine, and kopexil are discussed as alternatives to minoxidil for hair growth, with concerns about dependence. Minoxidil is noted for its effectiveness in transitioning hair growth phases, but dependence is mainly linked to androgenic alopecia.

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